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2007 1
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2020 2
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Page 1
A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.
Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP, Green MR. Sheng Z, et al. Nat Med. 2010 Jun;16(6):671-7. doi: 10.1038/nm.2158. Epub 2010 May 23. Nat Med. 2010. PMID: 20495567 Free PMC article.
Our results reveal an essential survival pathway in malignant glioma, whereby activation of a RAS-mitogen-activated protein kinase or phosphoinositide-3-kinase signaling cascade leads to induction of the transcription factor cAMP response element …
Our results reveal an essential survival pathway in malignant glioma, whereby activation of a RAS-mitogen-activated protein kinase or …
Transcriptomic-based toxicological investigations of ethanol to human umbilical vein endothelial cells.
Liu X, Zhang Y, Liu L, Zhu S. Liu X, et al. J Appl Toxicol. 2021 May;41(5):736-744. doi: 10.1002/jat.4084. Epub 2020 Oct 15. J Appl Toxicol. 2021. PMID: 33058231
The most significantly altered gene ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway after 5-mM ethanol treatment were nucleic acid binding (GO:0003676) and Herpes simplex virus 1 infection (ko05168), respectively, whereas the most significantl …
The most significantly altered gene ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway after 5-mM ethanol treatme …
Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells.
Würtemberger J, Tchessalova D, Regina C, Bauer C, Schneider M, Wagers AJ, Hettmer S. Würtemberger J, et al. PLoS One. 2020 Sep 8;15(9):e0238572. doi: 10.1371/journal.pone.0238572. eCollection 2020. PLoS One. 2020. PMID: 32898143 Free PMC article.
Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2), and CAMP Responsive Element Binding Protein 3 Like 2 (Creb3l2). This study e …
Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2), …
Identification of Novel SCIRR69-Interacting Proteins During ER Stress Using SILAC-Immunoprecipitation Quantitative Proteomics Approach.
Chen Y, Liu Y, Lin S, Yang S, Que H, Liu S. Chen Y, et al. Neuromolecular Med. 2017 Mar;19(1):81-93. doi: 10.1007/s12017-016-8431-9. Epub 2016 Aug 3. Neuromolecular Med. 2017. PMID: 27488499
Spinal cord injury and regeneration-related protein #69 (SCIRR69),also known as cAMP-responsive element-binding protein 3-like 2, belongs to the CREB/ATF family, some members of which play significant roles in ER stre …
Spinal cord injury and regeneration-related protein #69 (SCIRR69),also known as cAMP-responsive element-bindi …
Sclerosing Epithelioid Fibrosarcoma: A Distinct Sarcoma With Aggressive Features.
Warmke LM, Meis JM. Warmke LM, et al. Am J Surg Pathol. 2021 Mar 1;45(3):317-328. doi: 10.1097/PAS.0000000000001559. Am J Surg Pathol. 2021. PMID: 32769431
Tumors occurred primarily in the lower extremity (12), intra-abdominal area/visceral organs (9) and chest wall/paraspinal region (9) with a median size of 8.2 cm. The median follow-up was 49 months in 45 patients: 12 developed local recurrences and 36 developed metastases, …
Tumors occurred primarily in the lower extremity (12), intra-abdominal area/visceral organs (9) and chest wall/paraspinal region (9) with a …
Low-grade Fibromyxoid Sarcoma With Massive Degeneration: A Case of Unusual Gross and Histological Features.
Tasaki T, Shiba E, Noguchi H, Kirishima M, Kitazono I, Terabaru W, Tabata K, Higashi M, Shinohara N, Sasaki H, Nakajo M, Nakajo M, Hisaoka M, Tanimoto A. Tasaki T, et al. In Vivo. 2023 Nov-Dec;37(6):2863-2868. doi: 10.21873/invivo.13404. In Vivo. 2023. PMID: 37905642 Free PMC article.
Reverse transcriptase-polymerase chain reaction analysis detected mRNA expression of fused in sarcoma::CAMP-responsive element binding protein 3-like protein 2 (FUS::CREB3L2) fusion gene. Thus, a final diagnosi …
Reverse transcriptase-polymerase chain reaction analysis detected mRNA expression of fused in sarcoma::CAMP-responsive elem …
A novel EWS-CREB3L3 gene fusion in a mesenteric sclerosing epithelioid fibrosarcoma.
Dewaele B, Libbrecht L, Levy G, Brichard B, Vanspauwen V, Sciot R, Debiec-Rychter M. Dewaele B, et al. Genes Chromosomes Cancer. 2017 Sep;56(9):695-699. doi: 10.1002/gcc.22474. Epub 2017 Jul 1. Genes Chromosomes Cancer. 2017. PMID: 28569045
It has been recently characterized by recurrent pathogenic EWS-CREB3L1/2 or FUS-CREB3L2 fusions and common MUC4 protein expression by immunohistochemistry. ...Genomic profiling by array CGH, followed by RT-PCR and sequencing analysis, revealed a previously no …
It has been recently characterized by recurrent pathogenic EWS-CREB3L1/2 or FUS-CREB3L2 fusions and common MUC4 protein …
Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group.
Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchère-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marquès B, Aubain Somerhausen Nde S, Keslair F, Pedeutour F, Coindre JM. Guillou L, et al. Am J Surg Pathol. 2007 Sep;31(9):1387-402. doi: 10.1097/PAS.0b013e3180321959. Am J Surg Pathol. 2007. PMID: 17721195
Of all, 48/59 (sensitivity, 81%) LGFMS contained detectable transcripts (45 FUS-CREB3L2, 3 FUS-CREB3L1). Most relevant clinicopathologic features of fusion-positive LGFMS included predominance in lower extremities (22/48; thigh: 13/48), deep situation (46/48), and o …
Of all, 48/59 (sensitivity, 81%) LGFMS contained detectable transcripts (45 FUS-CREB3L2, 3 FUS-CREB3L1). Most relevant clinico …